Selenoprotein T (SELENOT)

Selenoprotein T (SELENOT) is a highly conserved, endoplasmic reticulum-resident selenoprotein containing a selenocysteine residue and functioning as an oxidoreductase. It plays a critical role in cellular redox regulation, maintaining calcium homeostasis in the ER, and modulating ER stress responses. SELENOT is essential for proper brain development, neuroprotection, and cell survival, as supported by lethality in knockout models. SELENOT is also implicated in the regulation of apoptosis, cell proliferation, glycoprotein N-glycosylation, and protein quality control. Alterations in its expression or function are linked to neurodegenerative diseases, ER stress-related conditions, and cancer. While some selenium-based compounds interact with and modulate SELENOT expression, no approved selective pharmacological inhibitors or activators are currently documented; nonetheless, SELENOT is considered a potential target for drug development in redox and ER stress-associated diseases.

Other names

Thioredoxin reductase-like selenoprotein TSELTSelTUNQ150/PRO176Thioredoxin reductase-like enzyme

Modulation of redox state, regulation of calcium storage in the ER, and modulation of ER stress and unfolded protein response.