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Target intelligence / Profile preview
Selenoproteins (SePs)
- Target
- SePs
- Molecular classification
- Enzymes, Antioxidant enzymes, Redox enzymes, Transport proteins, Other
01
Overview
Selenoproteins are a family of proteins containing selenocysteine (Sec), the 21st amino acid. They are essential for various biological functions, particularly antioxidant defense, redox regulation, and selenium transport. Selenoproteins are implicated in numerous diseases, including cardiovascular disease, cancer, and immune dysfunction. Their expression is regulated by dietary selenium intake.
- Other names
- Selenocysteine-containing proteinsSec proteins
02
Mechanism of action
Selenoproteins exert their effects through the catalytic activity of selenocysteine, which participates in redox reactions and other biological processes. Selenium supplementation can modulate selenoprotein expression and activity.
03
Biological functions
Antioxidant activityRedox regulationSelenium transportProtection against oxidative damageMetal bindingImmune responseThyroid hormone metabolism
04
Disease associations
Cardiovascular diseaseNeuromuscular disordersCancerMale infertilityInflammatory conditionsViral infectionsSelenium deficiency
05
Safety considerations
Selenium toxicity at high dosesPotential interactions with other antioxidantsVariations in selenoprotein gene expression and function among individuals
06
Interacting drugs
Selenium supplements
1 more in the full profile.
07
Biomarkers
Plasma Selenoprotein P (SelP) levels (reflecting selenium status)Selenoprotein expression levels in tissuesGlutathione peroxidase (GPX) activity
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