Semaphorin-3G (SEMA3G)

Semaphorin-3G is a secreted member of the class 3 semaphorin protein family, characterized by the presence of a sema domain and functioning primarily as a cell guidance cue in neuronal development and regulation of angiogenesis. SEMA3G binds neuropilin-2 (NRP2) to initiate signaling via associated plexin receptors, affecting vascular and neuronal cell behaviors by regulating migration, proliferation, and cell adhesion. In the vasculature, SEMA3G acts as an autocrine signal for endothelial cells and as a paracrine regulator for smooth muscle cells, with context-dependent pro- or anti-angiogenic activity. Its loss is associated with vascular instability and disease, and it plays additional roles in neural function, adipogenesis, and tumor suppression.

Other names

Semaphorin 3GSEMA3GFLJ00014sem2Semaphorin sem2semaphorin-3Gsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gsemaphorin sem2

Engages Neuropilin-2 (NRP2) receptor complexes, often with plexin co-receptors, to modulate downstream signaling, affecting cell migration, adhesion, and vascular integrity. Regulates β-catenin stability, thereby protecting endothelial junctions