Semaphorin-6A (SEMA6A)

Semaphorin-6A (SEMA6A) is a type I transmembrane glycoprotein belonging to the class 6 semaphorins, a conserved protein family critical in developmental processes including axon guidance, cell migration, synaptogenesis, and angiogenesis[2][3][6]. SEMA6A regulates an array of cellular functions: it can act as a repulsive guidance molecule for axons, modulate endothelial cell survival and vessel formation via VEGFR2 signaling, and influence cytoskeletal organization through interaction with the EVL protein and actin filaments[1][4][5][6]. SEMA6A plays physiologically significant roles in nervous system development, vascular maintenance, and potentially other organogenetic mechanisms. Mutations or altered expression are implicated in cancer, leukemia, developmental disorders, and vascular pathologies[6][1]. SEMA6A is considered a research therapeutic target due to its regulatory functions in key developmental and disease pathways, but no pharmacological agents or clinical biomarkers are currently approved for direct use against this molecule[6][2][1].

Other names

Semaphorin-6ASEMA6AKIAA1368SEMAQSema VIASEMA6A-1SEMA6A1HT018Semaphorin VIASemaphorin-6A-1sema VIa