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Semaphorin 6A antisense RNA 1 (SEMA6A-AS1)
- Target
- SEMA6A-AS1
- Molecular classification
- Other (long noncoding RNA; lncRNA; antisense RNA)
01
Overview
Semaphorin 6A antisense RNA 1 (SEMA6A-AS1) is a long non-coding RNA (lncRNA) transcribed from the antisense strand of the SEMA6A gene on chromosome 5. SEMA6A-AS1 overlaps with its sense counterpart SEMA6A and directly binds to SEMA6A mRNA, promoting its degradation and thereby downregulating SEMA6A protein expression. Functionally, SEMA6A-AS1 inhibits hepatocellular carcinoma (HCC) progression by suppressing cell proliferation, migration, and invasion, inducing cytoskeletal remodeling, and causing G1 cell cycle arrest. Reduced expression of SEMA6A-AS1 in HBV-related HCC is consistently associated with worse clinical outcomes and poor prognosis, making it a candidate prognostic biomarker and potential therapeutic target in liver cancer[1][2][3]. No drugs are currently known to act directly on SEMA6A-AS1, nor are there established drug mechanisms targeting it.
- Other names
- CTB-118N6.3SEMA6A-AS1
02
Biological functions
Negative regulation of cell proliferationNegative regulation of cell migrationNegative regulation of cell invasionRegulation of mRNA stability (of SEMA6A)Regulation of actin cytoskeletonCell cycle regulation (induction of G1 arrest)
03
Disease associations
Cancer (notably, hepatocellular carcinoma)
04
Biomarkers
Prognostic biomarker for hepatocellular carcinoma (HCC)[1][2][3]
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