Semaphorin-6B (SEMA6B)

Semaphorin-6B is a member of the semaphorin family, specifically the class 6 transmembrane semaphorins, and functions primarily as a cell-surface repellent influencing axon guidance, cell migration, and neural circuit development. It contains characteristic sema and PSI (plexin-semaphorin-integrin) domains, and is highly expressed in heart and brain tissues but also found throughout the body at lower levels. Semaphorin-6B has a well-documented role in neurodevelopment, especially in the guidance of mossy fibers in the hippocampus, and interacts with plexin family receptors, particularly Plexin A2 and A4. Genetic variants, including truncating and missense mutations, have been directly linked to progressive myoclonic epilepsy and may be relevant in other neurodevelopmental and oncologic diseases

Other names

Semaphorin 6BSEMA6BSEMANSEMAZUNQ1907/PRO4353Sema ZsemaZSEMA-VIBSEM-SEMA-ZSemaphorin-ZSema VIbsemaphorin Zsemaphorin VIBEPM11SEM-SEMA-Ysema domain, transmembrane domain (TM) and cytoplasmic domain(semaphorin) 6Bsemaphorin-6Ba

Not fully established for drugs; retinoic acid modulates SEMA6B via RXR/PPAR-mediated transcriptional repression