Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Amine Oxidase Copper-Containing 3 (AOC3)
- Target
- AOC3
- Molecular classification
- Enzyme, Adhesion molecule, Glycoprotein, Amine oxidase
01
Overview
Amine oxidase copper-containing 3 (AOC3), also known as vascular adhesion protein-1 (VAP-1), is a membrane-bound glycoprotein enzyme involved in both enzymatic and adhesive cellular functions. It catalyzes the oxidative deamination of primary amines, producing aldehydes, hydrogen peroxide, and ammonia. AOC3 also mediates leukocyte trafficking during inflammation by facilitating leukocyte binding and migration across endothelial cells. It's been implicated in inflammatory, vascular, and metabolic diseases.
- Other names
- VAP-1HPAOSSAOVascular adhesion protein-1Membrane primary amine oxidaseSemicarbazide-sensitive amine oxidase
02
Mechanism of action
Inhibition of amine oxidase activity; disruption of leukocyte adhesion
03
Biological functions
Amine oxidationLeukocyte adhesionLeukocyte migrationEndothelial cell adhesionMonoamine metabolismDetoxificationCell-cell interaction
04
Disease associations
InflammationInflammatory diseasesVascular diseasesAtherosclerosisMetabolic disordersDiabetesAdiposity
05
Safety considerations
Oxidative stress induction due to hydrogen peroxide production
06
Biomarkers
Soluble VAP-1/AOC3 in serum
Beyond the preview
Go deeper on Amine Oxidase Copper-Containing 3 (AOC3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Amine Oxidase Copper-Containing 3 (AOC3).