Senescence associated long non-coding RNA 1 (SALRNA1)

Senescence associated long non-coding RNA 1 (SALRNA1, also called SAL-RNA1 or XLOC_023166) is a long non-coding RNA identified in human cells, notably in type II alveolar epithelial cells. SALRNA1 is downregulated in cellular senescence and functions to modulate the SIRT1-FOXO3a/p53 signaling pathway, thereby reducing cellular senescence induced by stressors such as cigarette smoke. Experimental work suggests that upregulation or overexpression of SALRNA1 can reduce markers of senescence and apoptosis in lung epithelial cells, implicating it as a potential therapeutic target to ameliorate pathological aging processes, especially in lung diseases like COPD. SALRNA1 is considered part of the broader lncRNA family, a class of RNA molecules involved in epigenetic regulation and control of gene expression, with emerging roles in various disease pathologies

Other names

SAL-RNA1XLOC_023166lncRNA-SAL1

Modulation of SIRT1 signaling (SALRNA1 overexpression leads to upregulation of SIRT1, which decreases cellular senescence via regulation of FOXO3a and p53 transcription)