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Target intelligence / Profile preview
Senescent Cell Antigen (SCA)
- Target
- SCA
- Molecular classification
- Glycoprotein, Membrane protein
01
Overview
Senescent cell antigen (SCA) refers to a set of molecular changes or specific antigens appearing on the surface of senescent cells. These antigens are recognized by the immune system and play roles in both the physiological clearance of aged cells and in disease contexts such as cancer and age-related disorders. The classic SCA is a glycosylated polypeptide related to band 3 protein, but other cell types may express different senescence-associated surface markers. Immune recognition via these antigens is central for physiological removal but may also contribute to inflammation if clearance fails. SCAs are being investigated as targets for cancer immunotherapy and other age-related diseases.
- Other names
- Senescence-associated antigenAged cell antigen
02
Mechanism of action
N/A
03
Biological functions
Immune recognitionCell clearanceAntigen presentation
04
Disease associations
CancerAgingAge-related diseasesInflammation
05
Safety considerations
Potential for off-target effects in therapies targeting senescent cellsRisk of inducing autoimmunity if immune responses are not tightly controlled
06
Biomarkers
Surface expression on senescent cells
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