Target intelligence / Profile preview

Sentinel Lymph Node (None)

Target: None
Molecular classification: Lymph node, Immune system component, Anatomical structure

Overview

The sentinel lymph node is the first lymph node (or group of nodes) to which cancer cells are most likely to spread from a primary tumor. It acts as a "gatekeeper" for cancer metastasis, making its status a significant predictor for recurrence and overall survival. Sentinel lymph node biopsy (SLNB) is a standard practice for staging certain cancers and guiding further surgical intervention.

Mechanism of action

N/A

Biological functions

Lymph filtrationImmune responseCancer metastasis sentinelLymphatic drainage

Disease associations

Cancer metastasisTumor staging

Safety considerations

False negative resultsLymphedema (rare)Allergic reaction to dyesBleeding/infection

Biomarkers

Presence or absence of cancer cells in sentinel lymph node

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