Sentrin-specific protease 2 (SENP2)

Sentrin-specific protease 2 (SENP2) is a SUMO-specific isopeptidase enzyme that catalyzes both the processing of SUMO precursor proteins and the deconjugation (removal) of SUMO from target proteins.[3][4] SENP2 is distinguished by its unique capacity to associate with the inner nuclear membrane and nuclear pore complexes, regulated through N-terminal signals and an amphipathic α-helix promoting membrane interaction.[1] SENP2 has critical roles in the regulation of nucleoporin homeostasis, nuclear transport, and membrane-associated sumoylation, affecting cellular processes such as cell cycle progression, mitosis, mitochondrial dynamics, and neuronal excitability. Dysregulation of SENP2 function is implicated in pathologies including cancer and neurological disorders. SENP2 represents a potential, though currently untargeted, therapeutic node in diseases driven by aberrant sumoylation.[2][3][1]

Other names

SUMO specific peptidase 2KIAA1331Smt3ip2SMT3IP2DKFZp762A2316AXAM2SMT3-specific isopeptidase 2SUMO1/sentrin/SMT3 specific peptidase 2SUMO1/sentrin/SMT3 specific protease 2

Mechanisms of action are inferred—would be SUMO pathway inhibition or modulation; no approved drugs