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Septin-10 (SEPTIN10)
- Target
- SEPTIN10
- Molecular classification
- Cytoskeletal protein, GTPase, Septin family
01
Overview
Septin-10 (SEPTIN10) is a member of the septin family of cytoskeletal proteins that possess GTPase activity and can form filaments and higher-order oligomeric complexes[3][4][6]. These proteins localize to the cytoplasm and nucleus, contributing to processes such as cytokinesis, cytoskeletal organization, and cell division[3][4][6]. Septins, including Septin-10, interact with cellular membranes, actin filaments, and microtubules, and their assembly is regulated by nucleotide binding, post-translational modifications, and interaction with other proteins and cytoskeletal elements[1][4]. SEPTIN10 is implicated in a range of physiological and pathological processes, including the development and function of neurons, morphogenesis, and pathological conditions like cancer, neurodevelopmental disorders, and infertility[1][2][4]. There are currently no known drugs directly targeting Septin-10, and its therapeutic targeting remains unexplored[1][4].
- Other names
- Septin-10SEPTIN10SEPT10FLJ11619sept1-like4921515A04Rik9430099J10RIKLOC309891
02
Biological functions
Cytoskeletal organizationCytokinesisCell divisionFormation of septin filaments
03
Disease associations
CancerNeurodevelopmental disorders (e.g., Down syndrome, schizophrenia)Male infertilityNeuromuscular disordersBleeding disordersParkinson's disease (implied association)
04
Biomarkers
Alterations in septin expression (including SEPTIN10) have been used as biomarkers in infertility and cancer[1]
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