Septin-12 (SEPTIN12)

Septin-12 is a **guanine-nucleotide binding protein** in the septin family of cytoskeletal GTPases, encoded by the SEPTIN12 gene on human chromosome 16[2][3][1][6]. It forms filaments and interacts with other septins (such as SEPTIN7, SEPTIN6, SEPTIN2, SEPTIN4), especially at the sperm annulus, which is crucial for sperm tail integrity and motility[1][2]. Its primary role is in the morphogenesis and elongation of sperm heads and tails during spermatogenesis, likely via association with tubulins. Variants or dysfunction of SEPTIN12 are associated with specific types of male infertility, especially those related to sperm motility and structural defects[2][3][6]. There is no evidence that SEPTIN12 is targeted by any current therapies or used as a clinical biomarker, and it is not a conventional drug target such as a receptor or enzyme.

Other names

SEPTIN12Septin-12SEPT12SPGF10FLJ25410testicular tissue protein Li 168