Septin-2 (SEPT2)

Septin-2 (SEPT2) is a filament-forming cytoskeletal GTPase that is a core component of the septin family in humans, encoded by the SEPT2 gene[1][3]. Septin-2 participates in assembling septin complexes and filaments, which function as scaffolding structures involved in diverse cellular processes, including actin cytoskeletal organization, cytokinesis, cilium biogenesis, and cellular polarity. The protein interacts with other septins (such as SEPT6 and SEPT7), controls actin bundling, and is essential for the progression through mitosis and maintenance of chromosome stability[2][3]. SEPT2 is highly expressed in several tumor types and other diseases, influencing cell proliferation, migration, and invasion, and overexpression is linked to poor prognosis in cancers such as colorectal cancer and hepatocellular carcinoma[5]. No approved drugs selectively target SEPT2, but it is an area of interest for future therapeutic intervention due to its fundamental role in cytoskeletal dynamics and disease pathology[3][5][6].

Other names

Septin 2SEPTIN2DIFF6KIAA0158NEDD5NEDD-5hNedd5Pnutl3septin-2Neural precursor cell expressed developmentally down-regulated protein 5epididymis secretory sperm binding proteinneural precursor cell expressed, developmentally down-regulated 5

null (No marketed drugs directly target Septin-2. Mechanisms are theoretical, such as inhibition of GTPase activity or disruption of septin-actin complexes, based on experimental knockdown and cell studies.)