Septin-6 (SEPT6)

Septin-6 is a filament-forming cytoskeletal GTPase that is essential for normal organization of both the actin and microtubule cytoskeleton, playing a critical role in cytokinesis (cell division), formation and maintenance of cellular architecture, and membrane organization. It assembles into higher-order structures—rings and filaments—along microtubule and actin fibers, typically as part of heteromeric complexes with other septins such as SEPT7 and SEPT2. SEPT6 participates in protein sorting during multivesicular body biogenesis and regulates traffic of membrane proteins, particularly in neurons where it is highly expressed and associates with dendritic development. Mutations, aberrant expression, or chromosomal translocations involving SEPT6 are implicated in certain cancers and neuropathies. Structural studies have elucidated its coiled-coil regions, relevant for filament assembly and interfilament bridging, reinforcing its functional complexity in cellular architecture.

Other names

SEPTIN6SEP2SEPT2KIAA0128MGC16619MGC20339septin 6

N/A (no drugs directly targeting Septin-6 listed; mechanism would likely involve inhibition or modulation of GTPase activity or cytoskeletal filament formation if a drug existed)