Septin-7 (SEPTIN7)

Septin-7 is a highly conserved filament-forming cytoskeletal GTPase encoded on chromosome 7p14.4–14.1 and is unique among the 13 human septins as the sole member of its homology group. It is essential for the organization and function of the actin cytoskeleton, formation of septin filaments, and normal progression through the cell cycle. Septin-7 forms hetero-oligomeric complexes (e.g., 2/6/7/9) that assemble into hexamers, octamers, sheets, and rings, contributing to a wide range of biological processes including cell division, cellular architecture, migration, and mitochondrial function. Its altered expression is linked to various diseases, notably neurodegenerative disorders and cancers, and complete deletion leads to embryonic lethality due to loss of septin filament integrity. Septin-7 also plays key roles in development and regeneration of skeletal muscle, regulation of neuron morphogenesis, sperm annulus structure, and mechano-transduction signaling.

Other names

Septin-7SEPTIN7CDC10SEPT7CDC3SEPT7AhCdc10CDC10 protein homologNBLA02942

Inhibition/knockdown disrupts filament formation, cell division, morphogenesis, and mitochondrial integrity, leading to impaired cell proliferation and differentiation. Targeted by regulatory RNA (e.g., miR-127-3p) affecting proliferation. Acts as a scaffold for protein complexes, influencing downstream signaling and cytoskeletal remodeling.