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Sequestosome-1 (p62)
- Target
- p62
- Molecular classification
- Scaffold protein, Adaptor protein, Autophagy receptor
01
Overview
Sequestosome-1 (p62) is a multifunctional scaffold/adaptor protein involved in selective autophagy and the regulation of signaling pathways such as NF-kB and Nrf2. It acts as a cargo receptor for ubiquitinated proteins, facilitating their degradation via autophagy and the ubiquitin-proteasome system. p62 also plays a role in bone remodeling and is implicated in diseases such as Paget’s disease of bone, ALS, and FTLD. Its diverse functions are mediated by multiple functional domains, including PB1, ZZ-type zinc finger, TRAF6-binding domain, LIR/KIR motifs, and UBA.
- Other names
- SQSTM1Ubiquitin-binding protein p62
02
Mechanism of action
Modulation of autophagy, NF-kB and Nrf2 pathways.
03
Biological functions
Selective autophagyProtein degradationNF-kB signalingNrf2 antioxidant responseRegulation of cell survivalBone remodeling
04
Disease associations
Paget’s disease of boneAmyotrophic lateral sclerosis (ALS)Frontotemporal lobar degeneration (FTLD)Frontotemporal dementia
05
Biomarkers
p62-positive inclusions in ALS/FTLDSQSTM1 mutations in Paget's disease of bone
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