Serine and arginine-rich splicing factor 12 (SRSF12)

Serine and arginine-rich splicing factor 12 (SRSF12) is a member of the SR protein family, characterized by the presence of an N-terminal RNA recognition motif (RRM) and a C-terminal serine/arginine-rich (RS) domain[4][1][2]. SRSF12 acts as a splicing factor, participating in the recognition of splice sites and regulation of alternative mRNA splicing via the spliceosome[4][1][2]. It is predominantly expressed in the brain and testis and is mainly localized in the nucleus[2][4]. SRSF12, along with other SRSFs, plays a pivotal role in constitutive and alternative splicing, which is essential for accurate gene expression and mRNA diversity[1][2]. Aberrant expression or function of SRSF12 and related factors is implicated in the development of cancers and other diseases, likely through dysregulation of splicing events[1][2][4]. While the SR family as a whole has been proposed as a potential therapeutic target in oncology, there is currently no direct evidence or clinically relevant drugs that specifically target SRSF12[4][1][2].

Other names

SFRS13BSRS12Serine/arginine-rich splicing factor 12