Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Serine Beta-Lactamase (N/A)
- Target
- N/A
- Molecular classification
- Enzyme, Hydrolase
01
Overview
Serine beta-lactamases are bacterial enzymes that hydrolyze beta-lactam antibiotics, conferring resistance. They belong to Ambler classes A, C, and D and utilize a conserved serine residue in their active site for catalysis. They are clinically relevant due to their role in antibiotic resistance and are targeted by beta-lactamase inhibitors.
- Other names
- Class A beta-lactamasesClass C beta-lactamasesClass D beta-lactamasesPenicillinasesCephalosporinasesOxacillinasesESBLs (extended-spectrum beta-lactamases)
02
Mechanism of action
Acylation-deacylation mechanism: nucleophilic attack on the beta-lactam ring by a serine residue, followed by hydrolysis of the acyl-enzyme intermediate.
03
Biological functions
Hydrolysis of beta-lactam antibioticsDrug resistance
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Development of resistance mutationsLimited efficacy of beta-lactam antibioticsTreatment failure in bacterial infections
06
Interacting drugs
Penicillins
4 more in the full profile.
Beyond the preview
Go deeper on Serine Beta-Lactamase (N/A).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Serine Beta-Lactamase (N/A).