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Target intelligence / Profile preview
Serine Beta-Lactamase (Class C) (AmpC)
- Target
- AmpC
- Molecular classification
- Enzyme, Hydrolase, Serine hydrolase, Peptidase family S12
01
Overview
Serine beta-lactamases of class C, also known as cephalosporinases, are enzymes produced by various bacteria that confer resistance to β-lactam antibiotics, particularly cephalosporins. These enzymes hydrolyze the β-lactam ring of antibiotics, rendering them ineffective. They primarily hydrolyze cephalosporins but can act on other β-lactams. Common producers include Enterobacter cloacae (AmpC), Citrobacter freundii, Acinetobacter baumannii, Klebsiella pneumoniae, Salmonella enteritidis. These enzymes contribute significantly to antibiotic resistance in hospital-acquired infections.
- Other names
- Class C beta-lactamaseCephalosporinase
02
Mechanism of action
Hydrolyzes the beta-lactam ring of antibiotics via acylation and deacylation, rendering them inactive.
03
Biological functions
Hydrolysis of beta-lactam antibioticsBacterial defenseDrug resistance
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Contributes to antibiotic resistanceReduces effectiveness of beta-lactam antibioticsComplicates treatment of bacterial infections
06
Interacting drugs
Cephalosporins
2 more in the full profile.
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