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Target intelligence / Profile preview
Serine beta-Lactamase (Ambler Class D) (None)
- Target
- None
- Molecular classification
- Enzyme, Hydrolase
01
Overview
Serine beta-lactamases of Ambler class D, also known as oxacillinases (OXAs), are enzymes produced by certain bacteria that confer resistance to beta-lactam antibiotics. These enzymes hydrolyze the beta-lactam ring, a critical structure in these antibiotics, rendering them ineffective against bacterial cell wall synthesis. They use a serine residue (Ser-67) at the active site for catalysis.
- Other names
- Oxacillinase(s)OXA-type β-lactamase(s)OXAsClass D β-lactamase
02
Mechanism of action
Hydrolysis of the beta-lactam ring via a serine-mediated mechanism, forming an acyl-enzyme intermediate and releasing an inactivated antibiotic molecule.
03
Biological functions
Hydrolysis of beta-lactam antibioticsBacterial resistance to antibiotics
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Antibiotic resistanceLimited efficacy of beta-lactam antibioticsTreatment challenges for infections caused by bacteria producing these enzymes
06
Interacting drugs
Penicillins
6 more in the full profile.
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