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Target intelligence / Profile preview
Serine beta-lactamase (class D)
- Molecular classification
- Enzyme, Hydrolase
01
Overview
Serine beta-lactamases (class D) are enzymes produced by bacteria that confer resistance to β-lactam antibiotics—including penicillins, cephalosporins, and carbapenems—by hydrolyzing the β-lactam ring of these drugs. They are a major clinical concern due to their ability to inactivate a broad spectrum of antibiotics. They belong to the serine-dependent group, using an active site serine for catalysis. Also known as OXA-type beta-lactamases due to their oxacillin-hydrolyzing activity.
- Other names
- OXA-type beta-lactamasesClass D beta-lactamases
02
Mechanism of action
Hydrolyzes the beta-lactam ring of beta-lactam antibiotics via an active-site serine residue and a unique N-carboxylated lysine residue.
03
Biological functions
Antibiotic resistanceHydrolysis of beta-lactam antibiotics
04
Disease associations
Infection
05
Safety considerations
Multidrug resistanceEvolution of new substrate specificitiesHospital-acquired infections
06
Interacting drugs
Penicillins
2 more in the full profile.
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