Serine biosynthesis pathway

The serine biosynthesis pathway is a central metabolic route that converts glycolytic intermediate 3-phosphoglycerate to L-serine via three primary enzymatic steps involving phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT), and phosphoserine phosphatase (PSPH)[1][2][3][5]. L-serine is a nonessential but proteinogenic amino acid fundamental for protein, nucleotide, and phospholipid biosynthesis, as well as for providing one-carbon units required for methylation reactions[1][2][5]. The activity of this pathway supports cell proliferation and growth, making it critically important in rapidly dividing cells such as cancer cells[3]. Pathological alterations in this pathway are associated with congenital serine deficiency syndromes and play roles in tumor metabolic reprogramming[2][3].

Other names

Serine synthesis pathwaySerine production pathwayL-serine biosynthesisPhosphorylated pathway of serine biosynthesisSerine synthesis

Enzyme inhibition (notably of PHGDH, the first committed enzyme in the pathway)