Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Serine Endoprotease Furin (Furin)
- Target
- Furin
- Molecular classification
- Enzyme, Serine Protease, Subtilisin-like proprotein convertase
01
Overview
Furin is a calcium-dependent serine endoprotease primarily located in the Golgi apparatus. It belongs to the subtilisin-like proprotein convertase family and is responsible for processing precursor proteins into their active forms by cleaving at paired basic amino acid sites. Furin plays a crucial role in activating numerous proproteins involved in diverse biological processes, including hormone maturation, growth factor activation, and viral pathogenesis. Aberrant furin activity is implicated in various diseases, making it a potential therapeutic target.
- Other names
- PACEPaired basic Amino acid Cleaving Enzyme
02
Mechanism of action
Proteolytic cleavage of proproteins at specific consensus sequences
03
Biological functions
Proteolytic activation of precursor proteinsProtein processingRegulation of hormone activityRegulation of growth factor activityViral entry/activation
04
Disease associations
Infectious diseasesCancerIron metabolism disorders (e.g., juvenile hemochromatosis)
05
Safety considerations
Potential for off-target effects due to broad substrate specificityInhibition may affect normal cellular processesTherapeutic challenges related to targeting an enzyme with diverse functions
Beyond the preview
Go deeper on Serine Endoprotease Furin (Furin).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Serine Endoprotease Furin (Furin).