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Serine Hydrolase (None)

Target: None
Molecular classification: Enzyme

Overview

Serine hydrolases are a large and diverse enzyme superfamily characterized by a conserved serine residue at their active site, which is essential for their catalytic activity. They catalyze the hydrolysis of ester, amide, or thioester bonds in a wide range of substrates. They play critical roles in metabolism, signal transduction, and proteostasis and are implicated in various diseases, making them attractive targets for drug development.

Mechanism of action

Covalent modification of the active-site serine residue, leading to irreversible enzyme inhibition.

Biological functions

MetabolismSignal transductionProteostasisHydrolysis of ester bondsHydrolysis of amide bondsHydrolysis of thioester bonds

Disease associations

CancerNeurodegenerative diseaseMetabolic disordersInflammation

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