Serine hydrolase like protein 2 (SERHL2)

Serine hydrolase like protein 2 (**SERHL2**) is a poorly characterized human protein encoded by the **SERHL2** gene, found at chromosome 22q13.1[4]. It is annotated as a putative member of the alpha/beta hydrolase superfamily based on sequence similarity, and is predicted to possess hydrolase activity, but its endogenous substrate(s), physiological function, and molecular partners have not been experimentally determined[1][7]. The protein has been linked genetically to at least one disorder (Ataxia-Telangiectasia-Like Disorder 1), but direct mechanistic or clinical relevance is unclear[7]. Predicted to localize in cytoplasmic vesicles and primarily expressed at low specificity across normal tissues; no drug targeting or biomarker use is established. **Note:** - There is **no evidence** that SERHL2 is currently recognized as a direct therapeutic target (such as an an enzyme critical for disease, a receptor, or transport molecule) or that it is druggable or under investigation in drug development pipelines. - Functional and clinical annotation for human SERHL2 is limited. Most data are computational (predictive) or based on sequence homology without direct experimental validation in humans[7][1][3].

Other names

SERHL2SERHLserine hydrolase-like protein 2dJ222E13.1testis secretory sperm-binding protein Li 216e

Unknown; any reported interaction is not associated with a known therapeutic mechanism