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Target intelligence / Profile preview
Serine hydroxymethyltransferase
- Molecular classification
- Enzyme, PLP-dependent enzyme
01
Overview
Serine hydroxymethyltransferase (SHMT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate (THF) to glycine and 5,10-methylene-tetrahydrofolate (MTHF). This reaction is central to one-carbon metabolism and provides one-carbon units for nucleotide biosynthesis. SHMT is essential for cell proliferation and has been investigated as a potential target for anticancer drugs.
- Other names
- SHMTglyA gene product (in bacteria)SHMT1 (cytosolic isoform in humans)SHMT2 (mitochondrial isoform in humans)
02
Mechanism of action
Inhibition of serine hydroxymethyltransferase leading to disruption of nucleotide biosynthesis.
03
Biological functions
One-carbon metabolismNucleotide biosynthesisGlycine biosynthesisCell proliferation
04
Disease associations
Cancer
05
Safety considerations
Potential for disruption of normal cell function due to broad expression of SHMT.
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