Serine hydroxymethyltransferase 1 pseudogene 1 (SHMT1P1)

SHMT1P1 (SHMT-ps1) is a processed pseudogene originating from the cytosolic serine hydroxymethyltransferase 1 gene (SHMT1). It is located on the short arm of chromosome 1 and exists specifically in the primate order, having arisen via reverse transcription after the divergence of primates from other mammals. SHMT1P1 contains unique sequence features—such as deletions, insertions, and single-base mutations—used to track primate phylogenetics and molecular lineage. Unlike its functional parent gene, SHMT1, SHMT1P1 does not encode an active protein or contribute to metabolic processes, disease mechanisms, or serve as a therapeutic target[2][1][3][5].

Other names

SHMT1 pseudogene 1SHMT-ps1SHMT1P1

Not applicable; as a non-functioning pseudogene, there is no mechanism of action relevant to pharmacology.