Serine incorporator 3 (SERINC3)

Serine incorporator 3 (SERINC3) is a multipass transmembrane protein and member of the SERINC family, which facilitates the incorporation of serine into membrane phospholipids and sphingolipids, and functions as a lipid transporter and membrane scramblase[1][3][5]. It is expressed in the plasma membrane, is involved in the innate immune response against viruses as a restriction factor (especially HIV-1, by inhibiting viral fusion and entry), and is part of core lipid metabolic processes[1][5]. SERINC3 has roles in tissue-specific gene regulation, is subject to extensive posttranslational modification, and exhibits sequence variation that can impact protein function and regulation[2]. Disease associations include hereditary neuropathies, Duane retraction syndrome, alterations in bone and metabolic biomarkers, and potential links to tumor biology[1][4][5]. No clinically approved drugs are known to specifically target SERINC3, but its antiviral properties are of growing research interest.

Other names

SERC3SERC3_HUMANQ13530SERINC family member 3

Restriction of viral infectivity (retroviruses) by impeding membrane fusion/viral entry, specifically for HIV-1 and other lentiviruses