Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Serine Palmitoyltransferase
- Molecular classification
- Enzyme, Transferase, Acyltransferase
01
Overview
Serine palmitoyltransferase (SPT) is a key enzyme in sphingolipid metabolism, catalyzing the first and rate-limiting step in the de novo biosynthesis of sphingolipids. It condenses L-serine and palmitoyl-CoA to form 3-ketodihydrosphingosine, which is subsequently converted into various complex sphingolipids essential for cell membrane structure and function. Dysregulation or mutation of SPT subunits can lead to altered sphingolipid profiles associated with neurodegenerative diseases like Hereditary sensory neuropathy type I (HSAN-I).
02
Mechanism of action
Inhibition of serine palmitoyltransferase activity
03
Biological functions
Sphingolipid biosynthesisCell membrane structureCell signalingRegulation of cell growthRegulation of cell differentiationRegulation of apoptosisRegulation of stress responses
04
Disease associations
Hereditary sensory neuropathy type I (HSAN-I)Neurodegenerative disease
05
Safety considerations
Potential for neurotoxicity due to accumulation of atypical sphingoid basesDysregulation can lead to altered sphingolipid profiles
06
Interacting drugs
Myriocin
Beyond the preview
Go deeper on Serine Palmitoyltransferase.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Serine Palmitoyltransferase.