Serine palmitoyltransferase long chain base subunit 1 pseudogene 1 (SPTLC1P1)

Serine palmitoyltransferase long chain base subunit 1 pseudogene 1 (SPTLC1P1) is classified as a pseudogene and does not encode a functional protein. It is related by sequence to the protein-coding gene SPTLC1, which encodes a subunit of serine palmitoyltransferase, a critical enzyme in sphingolipid biosynthesis. SPTLC1P1 itself does not participate in enzymatic activity or known biological pathways; there is no evidence it serves as a drug target or biomarker, nor is it implicated in disease. Pseudogenes like SPTLC1P1 are generally regarded as nonfunctional DNA segments, though some pseudogenes in other contexts may have regulatory roles; none are described or confirmed for SPTLC1P1 in available data. SPTLC1 (not SPTLC1P1) is a protein-coding gene with a known biological role and disease associations such as hereditary sensory neuropathy type I. SPTLC1P1 is just one of several SPTLC1-related pseudogenes, with no evidence it is itself a therapeutic target or has related functions.