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Serine protease 12 (PRSS12)
- Target
- PRSS12
- Molecular classification
- Enzyme, Serine protease, Peptidase S1 family
01
Overview
Serine protease 12 (PRSS12), also known as neurotrypsin, is a secreted trypsin-like serine protease primarily expressed in neurons and found at synapses. It contains domains characteristic of protein family S1, including a Kringle domain and scavenger receptor cysteine-rich regions. PRSS12 cleaves the heparan sulfate proteoglycan agrin, which is essential for the formation and maintenance of excitatory synapses. Its activity is linked to neuronal plasticity and learning; mutations cause an autosomal recessive form of intellectual disability, highlighting its importance in cognitive development[1][2][4][7].
- Other names
- NeurotrypsinMotopsinBrain-specific serine protease 3BSSP-3MRT1LeydinProtease, serine 12
02
Mechanism of action
Proteolytic cleavage of extracellular matrix proteins (notably agrin) at synapses, contributing to structural plasticity
03
Biological functions
Neuronal plasticityProteolysis of agrin at synapsesStructural reorganization of synapsesLearning and memory
04
Disease associations
Intellectual developmental disorder (autosomal recessive, e.g., MRT1)Cognitive impairmentNeurodevelopmental disorders
05
Safety considerations
Potential for central nervous system effects if modulated, since it is crucial for synaptic plasticity and cognitive function
06
Biomarkers
Deficiency or mutations are used as biomarkers for autosomal recessive non-syndromic intellectual disability
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