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Serine protease 27 (PRSS27)

Target: PRSS27
Molecular classification: Enzyme, Serine protease, Trypsin-like serine protease, Secreted protease

Overview

Serine protease 27 (PRSS27) is a secreted tryptic serine protease enzyme mainly expressed in the pancreas, encoded by the PRSS27 gene on chromosome 16 in humans[1][4][5]. It belongs to the group-1 subfamily of serine proteases and contributes to protein digestion and processing in the digestive tract. Various transcript variants are produced through alternative splicing[1]. PRSS27 has enzymatic activity characteristic of serine-type endopeptidases, and dysregulation may be associated with diseases such as necrotizing gastritis[1][4].

Other names: MarapsinPancreasinMPNCAPH2Channel-activating protease 2protease serine 27UNQ1884/PRO4327

Biological functions

Protein catabolismDigestionSerine-type endopeptidase activityExtracellular protein processing

Disease associations

Necrotizing gastritispotential links to digestive system diseases

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