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Target intelligence / Profile preview
Serine/threonine-protein kinase TBK1 (TBK1)
- Target
- TBK1
- Molecular classification
- Enzyme, Serine/threonine protein kinase
01
Overview
Serine/threonine-protein kinase TBK1 (Tank-binding kinase 1, TBK1) is a critical enzyme involved in the regulation of innate immunity, inflammation, and several other cellular processes. It mediates signaling downstream of pattern recognition receptors such as Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), and STING-mediated cytosolic DNA sensors. TBK1 phosphorylates interferon regulatory factors IRF3 and IRF7, initiating transcription of type I interferon genes and other pro-inflammatory cytokines. Beyond antiviral defense, TBK1 regulates cell proliferation, apoptosis, autophagy, energy homeostasis, and anti-tumor immunity. Dysregulation can contribute to autoimmune diseases, neurodegeneration, or cancer development.
- Other names
- Tank-binding kinase 1
02
Mechanism of action
Kinase inhibitor
03
Biological functions
Innate immune responseType I interferon productionNF-kB pathway modulationAutophagy inductionCell proliferationApoptosisEnergy homeostasisAnti-tumor immunity
04
Disease associations
Autoimmune disordersNeurodegenerative diseaseCancerInflammation
05
Safety considerations
Excessive inflammatory signalingImpaired autophagyTumorigenesisModulation of immune surveillance
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