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Neisseria meningitidis Capsular Polysaccharides (Serogroups A, C, Y, and W-135) (Nm CPS (A, C, Y, W-135))
- Target
- Nm CPS (A, C, Y, W-135)
- Molecular classification
- Polysaccharide, Capsular Polysaccharide
01
Overview
Neisseria meningitidis capsular polysaccharides are high-molecular-weight carbohydrate polymers that form the outer capsule of the bacterium. Serogroups A, C, Y, and W-135 are clinically significant and are targeted by vaccines. The capsule protects the bacterium from phagocytosis and complement-mediated killing, acting as a major virulence factor. These polysaccharides serve as antigens in vaccines to induce protective immunity against invasive meningococcal disease.
- Other names
- Meningococcal Polysaccharide CapsuleSerogroup A Capsular PolysaccharideSerogroup C Capsular PolysaccharideSerogroup Y Capsular PolysaccharideSerogroup W-135 Capsular Polysaccharide
02
Mechanism of action
Antibody-mediated neutralization and opsonization, complement activation
03
Biological functions
Immune evasionVirulence factorCapsule formation
04
Disease associations
MeningitisSepticemiaInfection
05
Safety considerations
Hypersensitivity reactions to vaccine components
06
Interacting drugs
NmVac4-A/C/Y/W-135
1 more in the full profile.
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