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Target intelligence / Profile preview
Serotonin (5-HT)
- Target
- 5-HT
- Molecular classification
- Monoamine neurotransmitter, Hormone, Indoleamine
01
Overview
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter and hormone primarily found in the gastrointestinal tract, blood platelets, and central nervous system. It plays diverse roles in mood regulation, sleep, appetite, digestion, blood clotting, and various cognitive functions. Imbalances in serotonin levels or signaling are implicated in a range of mental and physical health conditions.
- Other names
- 5-hydroxytryptamineEnteramineThrombocytin
02
Mechanism of action
SSRIs inhibit the reuptake of serotonin from the synaptic cleft, increasing its availability. MAOIs inhibit the breakdown of serotonin.
03
Biological functions
Mood regulationSleep regulationAppetite controlDigestion and gut motilityBlood clotting (platelet aggregation)Learning and memory formationSexual behavior modulationPain perception modulationVasoconstriction
04
Disease associations
DepressionAnxiety disordersObsessive-compulsive disorderSocial anxiety disorderPanic disorderPost-traumatic stress disorder (PTSD)Irritable bowel syndrome (IBS)Migraine headachesSleep disturbances
05
Safety considerations
Serotonin syndrome (with excessive serotonergic activity)Gastrointestinal side effectsSexual dysfunctionWithdrawal symptoms
06
Interacting drugs
Selective serotonin reuptake inhibitors (SSRIs)
4 more in the full profile.
07
Biomarkers
Serotonin levels in bloodSerotonin transporter (SERT) binding potential
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