Target intelligence / Profile preview

Serotonin receptor 1A (5-hydroxytryptamine receptor 1A) (5-HT1A)

Target: 5-HT1A
Molecular classification: G protein-coupled receptor, Receptor

Overview

The serotonin 1A receptor (5-HT1A) is a subtype of serotonin receptors, part of the G protein-coupled receptor (GPCR) family. It binds the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT). It primarily couples to Gi/Go proteins, inhibiting adenylyl cyclase activity and activating inwardly rectifying potassium channels. 5-HT1A receptors are found as autoreceptors on serotonergic neurons in the raphe nuclei and as heteroreceptors on postsynaptic neurons elsewhere in the brain. It is involved in mood, anxiety, cognition, and hormone secretion and is a target for antidepressants and anxiolytics.

Other names: Serotonin 1A receptor5-hydroxytryptamine receptor 1AHTR1A

Mechanism of action

Agonism (anxiolytic/antidepressant), Antagonism (cognitive enhancement), Indirect modulation via increased synaptic serotonin availability (SSRIs)

Biological functions

Signal transductionMood modulationAnxiety modulationCognition modulationMemory formationAggression controlRegulation of hormone secretionNeuronal hyperpolarization

Disease associations

Major depressive disorder (MDD)Anxiety disordersCognitive disorders

Interacting drugs

SSRIs

2 more in the full profile.

Biomarkers

Genetic polymorphisms associated with susceptibility to depression/anxiety traits

Beyond the preview

Go deeper on Serotonin receptor 1A (5-hydroxytryptamine receptor 1A) (5-HT1A).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Serotonin receptor 1A (5-hydroxytryptamine receptor 1A) (5-HT1A).

Explore the full profile