Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Serotonin 1B Receptor (5-HT1B)
- Target
- 5-HT1B
- Molecular classification
- G protein-coupled receptor, GPCR, Class A GPCR, Rhodopsin-like GPCR, Receptor
01
Overview
The serotonin 1B receptor (5-HT1B) is a G protein-coupled receptor (GPCR) primarily coupled to Gi/o proteins. It acts mainly as an inhibitory presynaptic receptor, inhibiting the release of serotonin and other neurotransmitters. It is involved in various physiological functions, including mood regulation, anxiety, aggression, and vasoconstriction, particularly in cerebral arteries. It is a target for triptan drugs used in acute migraine therapy.
- Other names
- 5-Hydroxytryptamine Receptor 1BHTR1B
02
Mechanism of action
Agonists suppress neurotransmitter release by decreasing cAMP formation. Antagonists/inverse agonists block the receptor or stabilize inactive conformations.
03
Biological functions
Signal transductionNeurotransmitter release inhibitionVasoconstrictionModulation of moodModulation of anxietyModulation of aggressionRegulation of serotonin levelsRegulation of dopamine releaseRegulation of glutamatergic transmission
04
Disease associations
MigraineAddictionObsessive-compulsive disorderMood disordersAnxiety disorders
05
Safety considerations
Cardiovascular side effects (vasoconstriction)Potential for abuse (addiction pathways)
06
Interacting drugs
Triptans
2 more in the full profile.
Beyond the preview
Go deeper on Serotonin 1B Receptor (5-HT1B).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Serotonin 1B Receptor (5-HT1B).