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Target intelligence / Profile preview
Serotonin 1D Receptor (HTR1D)
- Target
- HTR1D
- Molecular classification
- G protein-coupled receptor, GPCR, Class A GPCR, Receptor
01
Overview
The serotonin 1D receptor (5-HT1D) is a G protein-coupled receptor that mediates inhibitory neurotransmission in the central nervous system. It is primarily known for its role in cranial vasoconstriction, making it a key target for migraine therapies. Activation of the 5-HT1D receptor inhibits adenylate cyclase activity, leading to decreased cAMP levels and reduced neuronal activity. Triptans, such as sumatriptan and zolmitriptan, are commonly used agonists at this receptor for the acute treatment of migraine.
- Other names
- 5-hydroxytryptamine receptor 1D5-HT1D receptor
02
Mechanism of action
Agonist at 5-HT1D receptor, leading to inhibition of adenylate cyclase and decreased cAMP levels, resulting in vasoconstriction.
03
Biological functions
NeurotransmissionModulation of locomotionModulation of anxietyVasoconstrictionSignal transduction
04
Disease associations
Migraine
05
Safety considerations
Potential for vasoconstriction-related adverse events (e.g., cardiovascular events) with triptans.Contraindications for triptans in patients with certain cardiovascular conditions.
06
Interacting drugs
Sumatriptan
1 more in the full profile.
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