Serotonin 2 Receptor (5-HT2 Receptor)

The serotonin 2 receptor (5-HT2 receptor) is a G protein-coupled receptor that plays key roles in neurotransmission and various physiological processes. It is comprised of three main subtypes: 5-HT2A, 5-HT2B, and 5-HT2C receptors. These receptors are involved in cognition, mood regulation, cardiac function, appetite control, and vasoconstriction. Drugs targeting this receptor family include psychedelics, antidepressants, and antipsychotics. Abnormalities in 5-HT2 receptor function are associated with psychiatric conditions such as depression, schizophrenia, and addiction, as well as cardiovascular side effects.

Other names

5-Hydroxytryptamine 2 Receptor

Agonists (e.g., LSD, psilocybin) stimulate the receptor. Antagonists (e.g., atypical antipsychotics) block the receptor. Activation leads to stimulation of phospholipase C (PLC), resulting in increased production of IP₃/DAG, intracellular calcium release, and activation of protein kinase C. Chronic administration of SSRIs and atypical antipsychotics leads to adaptive downregulation.