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Serotonin 2B Receptor (5-HT2B)
- Target
- 5-HT2B
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor, Class A/Rhodopsin-like GPCR
01
Overview
The serotonin 2B receptor (5-HT2B) is a G protein-coupled receptor (GPCR) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). It plays a role in cardiac valve maintenance, vascular effects, and modulation of serotonin/dopamine uptake in the central nervous system. Overstimulation can lead to adverse effects such as valvulopathy.
- Other names
- HTR2B
02
Mechanism of action
Agonist binding leads to Gq/11 protein activation, stimulating phospholipase C, increasing IP3/DAG, and elevating intracellular Ca2+.
03
Biological functions
Signal transductionCardiac valve maintenanceVascular contraction regulationModulation of serotonin/dopamine uptakeSerotonin transporter regulationRegulation of gene expression
04
Disease associations
Cardiovascular diseaseBipolar I disorderPulmonary hypertensionDepressionMood disordersCardiac valvulopathy
05
Safety considerations
Drug-induced heart valve disease (valvulopathy) due to chronic overstimulationCardiac hypertrophy
06
Interacting drugs
Serotonin
2 more in the full profile.
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