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Target intelligence / Profile preview
Serotonin 4 Receptor (5HT4)
- Target
- 5HT4
- Molecular classification
- G protein-coupled receptor, GPCR
01
Overview
The Serotonin 4 (5HT4) receptor is a G protein-coupled receptor that is activated by serotonin. It is primarily coupled to Gs proteins, leading to increased cAMP production. The receptor is expressed in the central nervous system (basal ganglia, cortex, hippocampus, amygdala) and peripheral tissues (gastrointestinal tract, bladder, heart). It plays a role in neurotransmitter modulation, gastrointestinal motility, mood regulation, and appetite control. Altered function or expression has been implicated in psychiatric disorders like depression and anxiety, as well as gastrointestinal disorders.
- Other names
- 5-HT4 receptorHTR4
02
Mechanism of action
Gs protein activation leading to increased cAMP production and downstream signaling pathways.
03
Biological functions
Neurotransmitter modulationRegulation of gastrointestinal motilityMood regulationAppetite controlCognitive enhancementSignal transduction
04
Disease associations
DepressionAnxiety disordersEating disordersGastrointestinal dysmotilityCognitive declineDementia
05
Interacting drugs
Agonists (e.g., for GI motility)
1 more in the full profile.
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