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Target intelligence / Profile preview
Serotonin 5-HT1B Receptor (5-HT1B)
- Target
- 5-HT1B
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor, Gi/o-coupled receptor
01
Overview
The serotonin 5-HT1B receptor (also known as 5-hydroxytryptamine receptor 1B) is a subtype of serotonin receptors encoded by the HTR1B gene. It belongs to the G protein-coupled receptor (GPCR) superfamily, specifically coupling to Gi/o proteins, and features seven transmembrane domains. The receptor primarily functions as an inhibitory receptor, modulating neurotransmitter release and playing critical roles across neurological functions such as mood, aggression, stress, anxiety, and memory. Its pharmacological targeting underpins several therapies for migraines and potentially psychiatric or neurodegenerative disorders.
- Other names
- 5-Hydroxytryptamine Receptor 1BHTR1B
02
Mechanism of action
Vasoconstriction via cerebral arteries; inhibition of neurotransmitter exocytosis via Gi/o protein activation
03
Biological functions
Signal transductionNeurotransmitter release regulationMood regulationAggression controlStress sensitivity responseAnxiety modulationMemory formation
04
Disease associations
MigraineDepressionAddictionObsessive-compulsive disorder (OCD)Alzheimer’s Disease
05
Interacting drugs
Sumatriptan
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