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Target intelligence / Profile preview
Serotonin 5-HT2B Receptor (5-HT2B)
- Target
- 5-HT2B
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor, GPCR Class A
01
Overview
The serotonin 5-HT2B receptor is a G protein-coupled receptor activated by serotonin. It plays roles in cardiac valve maintenance, serotonergic tone modulation, vascular contraction, and behavioral/mood regulation. Overactivation can lead to valvulopathy, while antagonism may have antidepressant properties. It is expressed in the CNS, cardiac valve leaflets and blood vessels. Activation stimulates phospholipase C, increasing intracellular calcium.
- Other names
- 5-hydroxytryptamine receptor 2BHTR2B
02
Mechanism of action
Gq protein activation leading to PLC activation, increased intracellular calcium, and downstream signaling pathways such as MAPK/ERK. Can also modulate serotonergic and dopaminergic neurotransmission.
03
Biological functions
Signal transductionCardiac valve maintenanceSerotonergic tone modulationVascular contractionBehavioral/mood regulationRegulation of serotonin releaseCell proliferation
04
Disease associations
Cardiovascular diseaseMood disordersValvulopathyDepression
05
Safety considerations
Valvular heart disease due to overstimulationCardiotoxicity
06
Interacting drugs
Serotonin
4 more in the full profile.
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