Target intelligence / Profile preview

Serotonin 5-HT2C Receptor (5-HT2C)

Target: 5-HT2C
Molecular classification: G protein-coupled receptor, GPCR, 5-HT2 receptor subfamily

Overview

The Serotonin 5-HT2C receptor (5-HT2C) is a G protein-coupled receptor belonging to the 5-HT2 receptor subfamily. Primarily expressed in the central nervous system, it plays a crucial role in regulating mood, anxiety, appetite, and motor function. It couples to Gq/G11 proteins, activating PLC, and can also activate PLA2. Drugs targeting this receptor are being investigated for the treatment of obesity and psychiatric disorders, particularly as adjuncts to SSRIs.

Other names: 5-Hydroxytryptamine Receptor 2CHTR2C

Mechanism of action

Gq/G11 protein activation leading to PLC activation, IP3 production, and increased intracellular calcium; PLA2 activation leading to RhoA/PLD pathway activation and ERK pathway stimulation.

Biological functions

Signal transductionRegulation of neurotransmitter releaseMood regulationAppetite controlMotor function regulationTemperature regulation

Disease associations

ObesityDepressionAnxietyDrug abuse/addictionParkinson's disease (potential)

Safety considerations

Potential side effects of agonists used for obesity treatmentNeed for careful modulation to avoid unwanted effects on mood, anxiety, or motor functionPolymorphisms in the HTR2C gene can lead to differential responses in males and females

Interacting drugs

Agonists (for obesity treatment)

2 more in the full profile.

Beyond the preview

Go deeper on Serotonin 5-HT2C Receptor (5-HT2C).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Serotonin 5-HT2C Receptor (5-HT2C).

Explore the full profile