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Serotonin 5-HT3 Receptor (5-HT3 receptor)
- Target
- 5-HT3 receptor
- Molecular classification
- Ligand-gated ion channel, Ionotropic receptor, Cys-loop superfamily, Receptor
01
Overview
The serotonin 5-HT3 receptor is a unique ligand-gated cation channel mediating fast excitatory signaling throughout both central and peripheral nervous systems. It plays critical roles ranging from emesis control to neurodevelopmental processes and serves as an important pharmacological target for antiemetic drugs.
- Other names
- 5-HT3HTR3Serotonin receptor 3
02
Mechanism of action
Antagonists block the receptor, inhibiting cation influx and reducing neuronal excitation. Agonists activate the receptor, increasing cation influx and neuronal excitation.
03
Biological functions
Fast excitatory neurotransmissionNeuronal depolarizationNeurotransmitter release regulationSynaptic transmissionGut motility/peristalsisMood regulationSynapse maturation
04
Disease associations
EmesisNauseaVomitingAnxietyMood disordersNeurodevelopmental disorders
05
Interacting drugs
Serotonin
1 more in the full profile.
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