Serotonin 5-HT5A receptor (5-HT5A receptor)

The Serotonin 5-HT5A receptor is a G protein-coupled receptor that binds serotonin and signals primarily through G_i/o proteins. It is expressed in multiple brain regions, including the raphe nuclei, cerebral cortex, hippocampus, and suprachiasmatic nucleus, implicating it in regulation of circadian rhythms, mood, cognitive function, and exploratory behavior. Despite its identification and cloning in the 1990s, the physiological roles of the 5-HT5A receptor have remained less defined compared to other serotonin receptors due to a shortage of selective ligands. Recent advances in structural biology (cryo-EM) and the discovery of selective antagonists have provided new tools for understanding its function and therapeutic potential. Emerging evidence points to a role for 5-HT5A in psychiatric disorders such as schizophrenia and depression

Other names

5-HT5A receptor5-hydroxytryptamine receptor 5AHTR5A

Agonists such as 5-CT activate the receptor, signaling via G_i/o proteins Antagonists (e.g., SB699551, ASP5736) block receptor activity