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Target intelligence / Profile preview
Serotonin 5-hydroxytryptamine 4 Receptor (5-HT4)
- Target
- 5-HT4
- Molecular classification
- GPCR, Serotonin receptor
01
Overview
The serotonin 5-HT4 receptor is a G protein-coupled receptor (GPCR) that binds the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT). It is encoded by the HTR4 gene. The receptor is a glycosylated transmembrane protein and exists in multiple isoforms. It modulates the release of various neurotransmitters and plays a role in cognition, mood regulation, appetite, and gastrointestinal motility. Agonists targeting this receptor are being explored for cognitive impairment, depression, and gastrointestinal motility disorders.
- Other names
- 5-Hydroxytryptamine receptor 4HTR4
02
Mechanism of action
Agonists stimulate adenylyl cyclase activity and increase intracellular cAMP, leading to enhanced neuronal excitability and increased acetylcholine release.
03
Biological functions
Signal transductionNeurotransmitter modulationNeuroplasticityNeurogenesisRegulation of gastrointestinal motility
04
Disease associations
Cognitive impairmentDepressionGastrointestinal motility disordersChronic constipationIrritable bowel syndrome (IBS)
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