Serotonin 5-hydroxytryptamine receptor 1A (None)

The serotonin 1A receptor, also known as the 5-HT1A receptor, is a subtype of serotonin (5-hydroxytryptamine, or 5-HT) receptors. It is a G protein-coupled receptor (GPCR) that binds the neurotransmitter serotonin and plays a key role in regulating mood, anxiety, and several other physiological processes. Activation of the human HTR1A gene product regulates dopamine and serotonin levels within the brain—affecting neural activity, mood regulation, behavior modulation, anxiety response, aggression control, appetite regulation, cognition/learning/memory processes—and influences sleep/wake cycles among others. It also induces secretion of hormones such as cortisol, ACTH (adrenocorticotropic hormone), oxytocin (linked to prosocial/anxiolytic effects), prolactin, growth hormone & β‑endorphin.

Other names

Serotonin receptor 1A5-hydroxytryptamine receptor 1AADRB2RL1G21

Agonist or antagonist binding to the 5-HT1A receptor, modulating downstream signaling pathways including adenylate cyclase activity, potassium channel opening, and calcium channel closing.