Serotonin 5-hydroxytryptamine receptor 1A subtype (None)

The serotonin 1A receptor (5-HT1A) is a subtype of serotonin receptors that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). It is one of the most abundant and widely distributed serotonin receptors in the brain and plays a crucial role in modulating mood, anxiety, cognition, and various neuroendocrine functions. It functions as both an autoreceptor on serotonergic neurons and a heteroreceptor on other neurons, mediating diverse physiological effects. It is a major target for drugs treating mood disorders such as depression and anxiety.

Other names

5-HT1A receptorSerotonin receptor 1AHTR1A

Agonist binding inhibits adenylyl cyclase activity, decreases cAMP levels, opens inwardly rectifying potassium channels leading to hyperpolarization, and inhibits voltage-gated calcium channels to reduce neurotransmitter release. Autoreceptor activation provides negative feedback to limit serotonergic signaling.